1212-1217 Murtaza LAJP 3371:Murtaza
نویسندگان
چکیده
Preparation and in vitro characterization of floating microparticles loaded with cimetidine (FMC) for oral delivery was the objective of this study. Non-solvent addition coacervation technique using hydroxypropylmethylcellulose (HPMC) as the rate controlling polymer was employed to achieve FMC. Three formulations of FMC were prepared and optimized regarding encapsulation efficiency and dissolution kinetics. Among all formulations, FMC2 having 1:3 ratio of cimetidine:HPMC exhibited the better in vitro performance regarding encapsulation efficiency and dissolution kinetics than that of FMC1 and FMC3. In conclusion, the FMC can be designed via non-solvent addition technique.
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